Real-world outcomes associated with standard half-life and extended half-life factor replacement products for treatment of haemophilia A and B
نویسندگان
چکیده
منابع مشابه
Tailoring treatment of haemophilia B: accounting for the distribution and clearance of standard and extended half-life FIX concentrates.
The prophylactic administration of factor IX (FIX) is considered the most effective treatment for haemophilia B. The inter-individual variability and complexity of the pharmacokinetics (PK) of FIX, and the rarity of the disease have hampered identification of an optimal treatment regimens. The recent introduction of extended half-life recombinant FIX molecules (EHL-rFIX), has prompted a thoroug...
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BACKGROUND Ferrets have long been used as a disease model for the study of influenza vaccines, but a more recent use has been for the study of human monoclonal antibodies directed against influenza viruses. Published data suggest that human antibodies are cleared unusually quickly from the ferret and that immune responses may be partially responsible. This immunogenicity increases variability w...
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ratio between the number of citations in a given year to any item published in that journal in the previous two years and the number of research items published in the same journal in the same two years. IF, widely acknowledged as the standard measure for scientific quality, places great emphasis on current research, favouring fast moving disciplines, while penalising slower moving topics; the ...
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The half-life of 87Rb was measured by a liquid scintillation method according to the efficiency tracing method. The measuring sample of rubidium chloride was dissolved in a scintillation cocktail of Insta-gel, and the rubidium was determined by gravimetry as tetraphenylborate. The result was (5.56 +/- 0.025) x 10(10) years.
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ژورنال
عنوان ژورنال: Blood Coagulation & Fibrinolysis
سال: 2020
ISSN: 0957-5235,1473-5733
DOI: 10.1097/mbc.0000000000000885